Antimalarial drugs – host targets (re)visited
Identifieur interne : 001D73 ( Main/Exploration ); précédent : 001D72; suivant : 001D74Antimalarial drugs – host targets (re)visited
Auteurs : Margarida Cunha-Rodrigues [Portugal] ; Miguel Prudêncio [Portugal] ; Maria M. Mota [Portugal] ; Werner Haas [Portugal]Source :
- Biotechnology Journal [ 1860-6768 ] ; 2006-03.
Abstract
Every year, forty percent of the world population is at risk of contracting malaria. Hopes for the erradication of this disease during the 20th century were dashed by the ability of Plasmodium falciparum, its most deadly causative agent, to develop resistance to available drugs. Efforts to produce an effective vaccine have so far been unsuccessful, enhancing the need to develop novel antimalarial drugs. In this review, we summarize our knowledge concerning existing antimalarials, mechanisms of drug‐resistance development, the use of drug combination strategies and the quest for novel anti‐plasmodial compounds. We emphasize the potential role of host genes and molecules as novel targets for newly developed drugs. Recent results from our laboratory have shown Hepatocyte Growth Factor/MET signaling to be essential for the establishment of infection in hepatocytes. We discuss the potential use of this pathway in the prophylaxis of malaria infection.
Url:
DOI: 10.1002/biot.200500038
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000796
- to stream Istex, to step Curation: 000796
- to stream Istex, to step Checkpoint: 000C41
- to stream Main, to step Merge: 001D85
- to stream Main, to step Curation: 001D73
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antimalarial drugs – host targets (re)visited</title>
<author><name sortKey="Cunha Odrigues, Margarida" sort="Cunha Odrigues, Margarida" uniqKey="Cunha Odrigues M" first="Margarida" last="Cunha-Rodrigues">Margarida Cunha-Rodrigues</name>
</author>
<author><name sortKey="Prudencio, Miguel" sort="Prudencio, Miguel" uniqKey="Prudencio M" first="Miguel" last="Prudêncio">Miguel Prudêncio</name>
</author>
<author><name sortKey="Mota, Maria M" sort="Mota, Maria M" uniqKey="Mota M" first="Maria M." last="Mota">Maria M. Mota</name>
</author>
<author><name sortKey="Haas, Werner" sort="Haas, Werner" uniqKey="Haas W" first="Werner" last="Haas">Werner Haas</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:E9EAFDD2B3575B9E156BAE0F1E7645BBC6CB79E5</idno>
<date when="2006" year="2006">2006</date>
<idno type="doi">10.1002/biot.200500038</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-7FLZB121-H/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000796</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000796</idno>
<idno type="wicri:Area/Istex/Curation">000796</idno>
<idno type="wicri:Area/Istex/Checkpoint">000C41</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000C41</idno>
<idno type="wicri:doubleKey">1860-6768:2006:Cunha Odrigues M:antimalarial:drugs:host</idno>
<idno type="wicri:Area/Main/Merge">001D85</idno>
<idno type="wicri:Area/Main/Curation">001D73</idno>
<idno type="wicri:Area/Main/Exploration">001D73</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Antimalarial drugs – host targets (re)visited</title>
<author><name sortKey="Cunha Odrigues, Margarida" sort="Cunha Odrigues, Margarida" uniqKey="Cunha Odrigues M" first="Margarida" last="Cunha-Rodrigues">Margarida Cunha-Rodrigues</name>
<affiliation wicri:level="1"><country xml:lang="fr">Portugal</country>
<wicri:regionArea>Unidade de Malária, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa</wicri:regionArea>
<wicri:noRegion>Lisboa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Prudencio, Miguel" sort="Prudencio, Miguel" uniqKey="Prudencio M" first="Miguel" last="Prudêncio">Miguel Prudêncio</name>
<affiliation wicri:level="1"><country xml:lang="fr">Portugal</country>
<wicri:regionArea>Unidade de Malária, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa</wicri:regionArea>
<wicri:noRegion>Lisboa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mota, Maria M" sort="Mota, Maria M" uniqKey="Mota M" first="Maria M." last="Mota">Maria M. Mota</name>
<affiliation wicri:level="1"><country xml:lang="fr">Portugal</country>
<wicri:regionArea>Unidade de Malária, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa</wicri:regionArea>
<wicri:noRegion>Lisboa</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Portugal</country>
</affiliation>
<affiliation></affiliation>
</author>
<author><name sortKey="Haas, Werner" sort="Haas, Werner" uniqKey="Haas W" first="Werner" last="Haas">Werner Haas</name>
<affiliation wicri:level="1"><country xml:lang="fr">Portugal</country>
<wicri:regionArea>Alfama, Taguspark, Porto Salvo</wicri:regionArea>
<wicri:noRegion>Porto Salvo</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Biotechnology Journal</title>
<title level="j" type="sub">Focus on Yeast</title>
<title level="j" type="alt">BIOTECHNOLOGY JOURNAL</title>
<idno type="ISSN">1860-6768</idno>
<idno type="eISSN">1860-7314</idno>
<imprint><biblScope unit="vol">1</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="321">321</biblScope>
<biblScope unit="page" to="332">332</biblScope>
<biblScope unit="page-count">12</biblScope>
<publisher>WILEY‐VCH Verlag</publisher>
<pubPlace>Weinheim</pubPlace>
<date type="published" when="2006-03">2006-03</date>
</imprint>
<idno type="ISSN">1860-6768</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1860-6768</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Every year, forty percent of the world population is at risk of contracting malaria. Hopes for the erradication of this disease during the 20th century were dashed by the ability of Plasmodium falciparum, its most deadly causative agent, to develop resistance to available drugs. Efforts to produce an effective vaccine have so far been unsuccessful, enhancing the need to develop novel antimalarial drugs. In this review, we summarize our knowledge concerning existing antimalarials, mechanisms of drug‐resistance development, the use of drug combination strategies and the quest for novel anti‐plasmodial compounds. We emphasize the potential role of host genes and molecules as novel targets for newly developed drugs. Recent results from our laboratory have shown Hepatocyte Growth Factor/MET signaling to be essential for the establishment of infection in hepatocytes. We discuss the potential use of this pathway in the prophylaxis of malaria infection.</div>
</front>
</TEI>
<affiliations><list><country><li>Portugal</li>
</country>
</list>
<tree><country name="Portugal"><noRegion><name sortKey="Cunha Odrigues, Margarida" sort="Cunha Odrigues, Margarida" uniqKey="Cunha Odrigues M" first="Margarida" last="Cunha-Rodrigues">Margarida Cunha-Rodrigues</name>
</noRegion>
<name sortKey="Haas, Werner" sort="Haas, Werner" uniqKey="Haas W" first="Werner" last="Haas">Werner Haas</name>
<name sortKey="Mota, Maria M" sort="Mota, Maria M" uniqKey="Mota M" first="Maria M." last="Mota">Maria M. Mota</name>
<name sortKey="Mota, Maria M" sort="Mota, Maria M" uniqKey="Mota M" first="Maria M." last="Mota">Maria M. Mota</name>
<name sortKey="Prudencio, Miguel" sort="Prudencio, Miguel" uniqKey="Prudencio M" first="Miguel" last="Prudêncio">Miguel Prudêncio</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D73 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001D73 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:E9EAFDD2B3575B9E156BAE0F1E7645BBC6CB79E5 |texte= Antimalarial drugs – host targets (re)visited }}
This area was generated with Dilib version V0.6.33. |